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KMID : 0942820080070020138
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Journal of Korean Brain Tumor Society
2008 Volume.7 No. 2 p.138 ~ p.143
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Outcome of Gamma Knife Radiosurgery for Nonfunctioning Pituitary Adenoma- Preliminary Report of Single Institution -
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Lee Seung-Joon
Kim Yong-Hwy
Chung Hyun-Tai
Paek Sun-Ha
Jung Hee-Won
Kim Dong-Gyu
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Abstract
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Objective: The purpose of this study is to survey the efficacy of gamma knife radiosurgery(GKS) in patients with nonfunctioning pituitary adenomas(NFPAs).
Materials and Methods: A total of 32 patients(14 males and 18 females) with NFPAs underwent GKS between 1998 and 2007. Among them, 27 patients(84%) underwent GKS for remnant or recurrent tumors after surgical resection. The median age of the patients was 51 years(range, 21-74). The median follow-up duration was 35 months(range, 12- 120). The median tumor volume was 2.5 cm3(range, 0.7-15.4). The median marginal dose was 15.0 Gy(range, 12.5- 19.0). The median number of shots was 7(range, 4-14).
Results: Tumor volume was decreased at the last follow-up in 18 patients(56.2%), and unchanged in 12(37.5%) patients. Fifteen patients experienced tumor shrinkage(46.9%) within 6 months after radiosurgery. Eventually 2 patients experienced tumor growth after radiosurgery. There were neither newly occurred panhypopituitarism nor visual deterioration after GKS. The actuarial tumor control rates were 96.7% and 90.2% at 1 and 3 years, respectively.
Conclusion: GKS is safe and effective in treating the patients with NFPAs, especially small remnant tumors after surgical resection which usually have enough distance from the optic apparatus. This is the preliminary result of a single center experience, and more cases with long-term follow-up duration will be necessary to verify the results of the present report.
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KEYWORD
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Gamma knife, Nonfunctioning pituitary adenoma, Radiosurgery
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